Detalhe da pesquisa
1.
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Cell
; 168(5): 817-829.e15, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28215705
2.
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Mol Pharm
; 15(9): 3979-3996, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30040421
3.
Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.
Mol Cell Proteomics
; 15(4): 1220-31, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26711467
4.
Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.
Bioorg Med Chem Lett
; 27(15): 3534-3541, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28606761
5.
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Nature
; 464(7287): 431-5, 2010 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20130576
6.
Diverse somatic mutation patterns and pathway alterations in human cancers.
Nature
; 466(7308): 869-73, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20668451
7.
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.
Genome Res
; 22(12): 2315-27, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23033341
8.
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proc Natl Acad Sci U S A
; 109(14): 5299-304, 2012 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431598
9.
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Proc Natl Acad Sci U S A
; 109(47): 19368-73, 2012 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23134728
10.
Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.
J Biol Chem
; 288(4): 2403-13, 2013 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23188824
11.
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.
Nat Med
; 13(1): 84-8, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17159987
12.
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Cancer Cell
; 9(5): 341-9, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697955
13.
A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.
Biochem J
; 452(2): 313-20, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23496764
14.
Selective inhibition of mutant Ras protein through covalent binding.
Angew Chem Int Ed Engl
; 53(15): 3777-9, 2014 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24590864
15.
Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I.
Cancer Res Commun
; 4(2): 540-555, 2024 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38358346
16.
Structure of the p53 degradation complex from HPV16.
Nat Commun
; 15(1): 1842, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38418456
17.
Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells.
Cancer Cell
; 2(6): 507-14, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12498719
18.
Genetic alterations and oncogenic pathways associated with breast cancer subtypes.
Mol Cancer Res
; 7(4): 511-22, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19372580
19.
Zinc finger nucleases as tools to understand and treat human diseases.
BMC Med
; 8: 42, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20594338
20.
Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival.
J Neurooncol
; 97(1): 33-40, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19705067